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Episodes
Friday Aug 10, 2018
Friday Aug 10, 2018
June 2007 Author in the Room® Teleconference
Author: Steven R. Steinhubl, MD
Article: "Aspirin Dose for the Prevention of Cardiovascular Disease"
Summary Points:
- While aspirin is generally a safe drug, and extremely effective, with over 50 million US adults taking it everyday for cardiovascular disease prevention, even a very small incidence of side-effects can have major implications. Consistent with this, one study found that the most common medication leading to an adverse event requiring hospitalization was aspirin for cardiovascular disease prevention.
- In terms of preventing heart attacks, strokes or cardiovascular deaths, no clinical trial has identified an aspirin dose more efficacious than 75 to 81mg daily.
- Although there is no dose of aspirin that doesn't increase the risk of GI toxicity or bleeding, greater doses of aspirin are consistently associated with a greater risk. For example, in the US alone, if everyone took 325mg of aspirin daily instead of 81mg, based on observational data, this could translate into nearly 1 million additional major bleeding complications a year.
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